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73 m2 or more between two successive examinations can therefore be considered as a significant change. Normal values Getting normal values in children, while these values are changing in function of age, represents a major challenge, since nothing such as real normal values can be obtained, because of evident ethical reasons. 21 They were selected retrospectively, on the basis of a simultaneous Tc99m DMSA acquisition, showing a normal left-to-right ratio (between 45–55%) and normal parenchymal imaging.
When the plasma concentration has reached a plateau. At this time, the input R is perfectly compensated by the output UV. The clearance is then simply given by: R C = ᎏᎏ P (5) The general principle is therefore to sample plasma until a plateau is reached and then to determine the plateau level P. The pump should be calibrated in flow and, most importantly, have a constant flow. The specific activity of the infused solution should be determined. To save time in reaching the plateau, a priming activity is injected as a bolus before infusion.
Major differences can be seen only for very high values and very low values (where single-sample techniques are not recommended). 20 However, among single-sample methods, only Christensen and Groth's and Russell's make it possible to choose time sampling. Single-sample methods are simple and they have proven accuracy. However, they rely on the exact determination of the injected dose and any error in this determination will induce a similar error in GFR. An advantage of a monoexponential method over single-sample methods is therefore that determining the distribution volume (which is of the order of the extracellular volume) may help to detect errors in the determination of the injected activity.
Into Space with Ace Brave! Space-Master