Read e-book online Infection and Autoimmunity PDF

By Y. Shoenfeld (Editor), Noel Richard Rose (Editor)

ISBN-10: 0080534651

ISBN-13: 9780080534657

ISBN-10: 0444512713

ISBN-13: 9780444512710

Autoimmune illnesses are stipulations the place the immune process assaults the physique organs rather than international invaders. This ebook offers with a few of the mechanisms which infectious brokers can set off autoimmunity reminiscent of molecular mimicry, polyclonal activation and others. an summary is given with reference to micro organism, viruses and parasites linked to autoimmunity. there's a precis on classical autoimmune illnesses and the infecting brokers that may set off them.

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In addition, the level of these spontaneously-arising T cell responses gradually increased with the duration and extent of exposure of F344 rats to the conventional environment. The functional significance of these BCTD-directed T cell responses was evident from results of adoptive transfer experiments: BCTD-restimulated (in vitro) splenic cells of naive CV-F344 rats could adoptively transfer protection against AA to naive BF-F344 recipients [52]. The above results present one of the mechanisms underlying the influence of housing environment on protection against an autoimmune disease.

Tuberculosis (H37Ra, heat-killed) challenge in the Wistar Kyoto (WKY) rats that possess the same MHC haplotype as the AA-susceptible Lewis rat but are resistant to induction of AA [4]. The simultaneous emergence of T cell responses to the pathogenic (180-188/ 177-191 determinant) and regulatory (BCTD) epitopes could explain, in part, the AA-resistance of WKY rats. The results of our recent study demonstrate that the C-terminal epitopes of self hsp65 are also disease-regulating in nature (Durai, Gupta and Moudgil, manuscript in press [51 a]).

Moudgil KD, Chang TT, Eradat H, Chen AM, Gupta RS, Brahn E et al. Diversification of T cell responses to carboxy-terminal determinants within the 65-kD heatshock protein is involved in regulation of autoimmune arthritis. J Exp Med 1997;185(7):1307-16. 5. Swanborg RH. Experimental autoimmune encephalomyelitis in the rat: lessons in T-cell immunology and autoreactivity.

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Infection and Autoimmunity by Y. Shoenfeld (Editor), Noel Richard Rose (Editor)

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