By Robert Coleman, David Fox, Geny Groothius, Colin Garner, Ellen Berg, Katherine Tsaioun, Gerry Thomas, Martin Brunner, Kelly BeruBe, James Hickman, David Bunton
This ebook will offer an in depth heritage and dialogue of using human tissues as a substitute to animal-based checking out for assessing the efficacy and protection of latest drugs. starting through offering the heritage and historical past of animal-based trying out, this article then describes intimately the problems in terms of entry to human cells and tissue and the foundations and laws governing their use. The e-book includes chapters on tissue slices, tradition, assays, microfluidics and body-on-a-chip know-how, in addition to chapters on rising applied sciences and methods reminiscent of engineered organs. each one bankruptcy comprehensively covers a strategy, from its utilisation and method to the possibilities and boundaries of the strategy. Written and edited by means of around the globe specialists in the box, this e-book might be a necessary textual content for biochemists and researchers operating in translational drugs in either and academia
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There are two key drivers in the use of human tissue: rstly, the failure of the current approach to drug development which demands new approaches to reduce clinical attrition, and secondly, the drive towards biomarkers for personalised medicine. The dominant approach to drug development, based on primary screening in high-throughput models and secondary screening in animals, has previously produced numerous ‘blockbuster’ drugs, but clinical attrition rates of 95% are no longer viewed as sustainable.
Med. , 2010, 686, 105. 48. M. Perera, J. R. Petrie, C. Hillier, M. Small, N. Sattar, J. M. Connell and M. A. Lumsden, Hum. , 2002, 17, 497. 49. B. H. C. Stricker, Br. Med. , 1992, 305, 118. CHAPTER 3 Translational Research in Pharmacology and Toxicology Using Precision-Cut Tissue Slices G. M. M. GROOTHUIS*a, A. CASINIa, H. MEURSb, AND P. OLINGAc a Division of Pharmacokinetics, Toxicology & Targeting, Department of Pharmacy, University of Groningen, A. Deusinglaan 1, 9713 AV Groningen, the Netherlands; bDivision of Molecular Pharmacology, Department of Pharmacy, University of Groningen, A.
Human-based Systems for Translational Research by Robert Coleman, David Fox, Geny Groothius, Colin Garner, Ellen Berg, Katherine Tsaioun, Gerry Thomas, Martin Brunner, Kelly BeruBe, James Hickman, David Bunton
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