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By Sohei Makino

ISBN-10: 3805577680

ISBN-13: 9783805577687

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Our results showed that in human eosinophils PAF activates two distinct signaling and effector pathways coupled to the PAF ABC © 2004 S. com/iaa receptor: one linked to PTX-sensitive G protein(s) and another to PTX-resistant G protein(s), phosphatidylinositol 3-kinase, and cellular adhesion. This activation of two different G proteins by the eosinophil PAF receptor may explain the strong and diverse biological responses of human eosinophils to PAF. Copyright © 2004 S. Karger AG, Basel Introduction Platelet-activating factor (PAF) has a variety of cellular functions [reviewed in 1, 2] including aggregation and secretion of platelets [2], aggregation and stimulation of neutrophils [3], activation of macrophages [4], an increase in vascular permeability in the skin [5], and contraction of guinea pig ileum and lung parenchymal strips [6, 7].

PPARÁ Regulates Eosinophil Functions 26 Kintscher U, Goetze S, Wakino S, Kim S, Nagpal S, Chandraratna RA, Graf K, Fleck E, Hsueh WA, Law RE: Peroxisome proliferatoractivated receptor and retinoid X receptor ligands inhibit monocyte chemotactic protein-1directed migration of monocytes. Eur J Pharmacol 2000;401:259–270. 27 Kampen GT, Stafford S, Adachi T, Jinquan T, Quan S, Grant JA, Skov PS, Poulsen LK, Alam R: Eotaxin induces degranulation and chemotaxis of eosinophils through the activation of ERK2 and p38 mitogen-activated protein kinases.

30 Wang N, Verna L, Chen NG, Chen J, Li H, Forman BM, Stemerman MB: Constitutive activation of peroxisome proliferator-activated receptor-Á suppresses pro-inflammatory adhesion molecules in human vascular endothelial cells. J Biol Chem 2002;277:34176–34181. 31 Couturier C, Brouillet A, Couriaud C, Koumanov K, Bereziat G, Andreani M: Interleukin 1ß induces type II-secreted phospholipase A(2) gene in vascular smooth muscle cells by a nuclear factor ÎB and peroxisome proliferatoractivated receptor-mediated process.

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Eosinophils in allergy and related diseases: proceedings of a workshop, Tokyo, Japan, June 21, 2003 by Sohei Makino


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