Environment and Breast Cancer - download pdf or read online

By Robert A. Hiatt (auth.), Jose Russo (eds.)

ISBN-10: 1441998950

ISBN-13: 9781441998958

ISBN-10: 1441998969

ISBN-13: 9781441998965

Breast melanoma is a fancy sickness because of a number of environmental and way of life components interacting with genetic susceptibility around the lifestyles span. as a result, environmental elements are of excessive curiosity to either researchers and group individuals, together with girls with breast melanoma. there isn't enough literature that addresses this factor comprehensively from epidemiological, experimental, and translational examine viewpoint. This e-book is aiming to fill this hole via amassing in eleven chapters the main well-known professional within the box of breast biology and melanoma with designated pursuits in environmental issues.

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2 Polychlorinated Biphenyls PCBs are a family of 209 possible organochlorine congers that were used as industrial coolants, insulators, and lubricants, as well as many other applications until the United States banned their use in 1979. Since then, decreasing human body burden concentrations have been documented over the last 20 years. As with DDT, PCBs have been inconsistently related to breast cancer in many studies of adult women using a variety of epidemiologic observational study designs, including occupational cohort studies (Engel et al.

2005) as did and 94% of samples tested in a study of prepubertal 6–7-year-old girls in the BCERCs across the US (Wolff et al. 2007). However, there is uncertainty as to the level and risk of exposure to BPA in humans. There are currently no epidemiologic studies of BPA and breast cancer in humans, but in Japanese studies associations have been found between BPA, circulating androgens and polycystic ovarian syndrome, repeated miscarriage, and endometrial hyperplasia (Hiroi et al. 2004; Sugiura-Ogasawara et al.

This chapter will examine the concept of puberty as a window of susceptibility. It will examine the hormonal events and anthropometric changes associated with puberty, potential mechanisms to explain how pubertal and reproductive events are associated with risk of breast cancer, and how environmental exposures – through chemicals, diet, and activity – may impact pubertal events as well as risk of breast cancer. 2 Physiologic Principles Underlying Puberty as a Window of Susceptibility The development of the mammary gland is regulated at three critical periods of development: during fetal life, at the time of puberty, and with pregnancy.

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Environment and Breast Cancer by Robert A. Hiatt (auth.), Jose Russo (eds.)


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