Download e-book for iPad: Drugs, addiction, and the brain by George F Koob; Michael A Arends; Michel Le Moal

By George F Koob; Michael A Arends; Michel Le Moal

ISBN-10: 0123869374

ISBN-13: 9780123869371

ISBN-10: 0123869595

ISBN-13: 9780123869593

Drugs, dependancy, and the Brain explores the molecular, mobile, and neurocircuitry platforms within the mind which are liable for drug habit. universal neurobiological parts are emphasised that offer novel insights into how the mind mediates the extreme lucrative results of gear of abuse and the way it adjustments throughout the transition from preliminary drug use to compulsive drug use and habit. The publication presents a close review of the pathophysiology of the illness. the data supplied can be priceless for neuroscientists within the box of habit, drug abuse remedy prone, and undergraduate and postgraduate scholars who're drawn to studying the various results of gear of abuse at the brain.

  • Full-color circuitry diagrams of mind areas implicated in each one degree of the habit cycle
  • Actual facts figures from unique resources illustrating key innovations and findings
  • Introduction to easy neuropharmacology phrases and concepts
  • Introduction to various animal types used to check assorted points of drug use.
  • Thorough evaluation of extant paintings at the neurobiology of addiction

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Additional resources for Drugs, addiction, and the brain

Sample text

Antidepressants are drugs that are used to treat major depressive episodes and include selective serotonin reuptake inhibitors, such as fluoxetine (trade name: Prozac) and escitalopram (trade name: Lexapro), among others. • Psychedelics are drugs that produce psychedelic experiences. Psychedelic can be defined as mind-altering. Another term that is often used to describe this drug class is hallucinogen, but the true meaning of the term hallucination is to experience something that is not there; therefore, the term psychedelic is preferred.

Degeneration of this system is the primary basis for many of the motor dysfunctions associated with Parkinson’s disease. 11). The mesocorticolimbic dopamine system projects from the ventral tegmental area to the nucleus accumbens, olfactory tubercle, amygdala, and frontal cortex. This system has been implicated in psychostimulant-induced locomotor activity, drug reward, and non-drug motivational attributes, such as incentive salience, conditioned reinforcement, and conditioned approach (for further reading, see Schultz, 2006).

In the body, and particularly the brain, antagonists can produce effects on their own by blocking an endogenous agonist. For example, a dopamine receptor antagonist can block the effects of a dopamine receptor agonist. On its own, however, the antagonist can produce motor initiation deficits by blocking the effects of endogenous dopamine. A drug that binds strongly to the binding site of the receptor with high affinity but is only partially effective (low efficacy) is termed a partial agonist (it partially activates the receptor).

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Drugs, addiction, and the brain by George F Koob; Michael A Arends; Michel Le Moal


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