Get Do seizures damage the brain PDF

By Thomas Sutula, Asla Pitkanen (Eds.)

ISBN-10: 0444508147

ISBN-13: 9780444508140

What are the results, if any, of repeated short seizures which are the defining function of epilepsy? an organization solution to this query has been unusually elusive for numerous purposes. basically there's a subset of sufferers who seem to tolerate seizures with really constrained long term outcomes, and never all sufferers are destined to development to intractability with widespread seizures and incapacity. This variability and person susceptibility has made it tricky to make statements that really observe to the total diversity of individuals with epileptic problems, whose problems span a extensive spectrum from light with very good regulate and few barriers, to serious with a number of day-by-day seizures and suggested incapacity that is affecting employment, academic functionality, an own life.This quantity seeks to discover the spectrum of serious to extra refined harm that could be a outcome of seizures. The contributing authors have addressed those questions and similar matters utilizing various equipment in experimental types and in sufferers with epilepsy.

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This is a simple method for avoiding double counts, and its particular strength is that it is completely independent of the size and shape of the objects being counted. That is, with this method, the two parameters, size and number, cannot be confused. If the two sections are physically separate sections (the 'physical disector') then the process is difficult because the two sections need to be precisely matched so that objects on one section can be matched against objects on the next section. Furthermore, the method often cannot be used on archival material where complete series may not be available, either because different stains were used for adjacent sections, or sections were not mounted as complete series.

1). I f all o f the profiles in the s a m p l e d parts o f the sections are c o u n t e d (profile counts), then the severity o f this bias, and the extent to w h i c h it can be r e c o g n i z e d and c o r r e c t e d d e p e n d s on h o w m u c h the o b s e r v e r k n o w s about the shape and the size o f the objects and the thickness o f the sections. T h e less one k n o w s about the shape and the Fig. 1. Schema to represent the use of the Abercrombie correction for a profile count.

Given the danger that the term 'assumption-free', when applied to a quantitative method, will lead to a false sense of security about the reliability of the results and their interpretation, it may be best for the term to he avoided altogether and replaced by a thoughtful and complete account of the tissues that have been used, and the methods employed to avoid a biased result. Acknowledgements We thank Dr. B. Pawley for helpful discussions of some of the optical problems, Dr. W. Stretton for helpful comments on an earlier draft, and Dr.

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Do seizures damage the brain by Thomas Sutula, Asla Pitkanen (Eds.)


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