Download e-book for kindle: Diagnosis and Management of Muscle Disease by Albert P. Galdi M.D. (auth.)

By Albert P. Galdi M.D. (auth.)

ISBN-10: 9401163359

ISBN-13: 9789401163354

ISBN-10: 9401163375

ISBN-13: 9789401163378

Neurologists and non-neurologists alike can not forget about ailments of the neuromuscular process. The outdated dogma that those problems are either unusual and untreatable has misplaced its validity. contemporary technological advances have enabled us to check extra accurately muscle and nerve anatomy, body structure and biochem­ istry. due to this development, we're now spotting new neuromuscular di­ seases in addition to diagnosing extra refined situations of myasthenia gravis, myotonia, and metabolic myopathies. remedy of the neuromuscular illnesses has additionally un­ dergone dramatic swap according to new discoveries within the fields of immunology and pharmacology. not are myotonia, periodic paralysis, and malignant hyperthermia untreatable clinical curiosities. now not are circumstances of steroid-un­ responsive myositis given up as hopeless. due to these types of advances, non-sur­ gical physicians and particularly neurologists needs to replace their wisdom regard­ ing the neuromuscular problems. This e-book, it really is was hoping, can help such clinicians in facing this activity. Emphasis has been put on the analysis and administration of those issues instead of on their pathophysiology. The extra unusual ailments and people of doubtful life were passed over purposely and left to the bigger and extra encyclopedic reference works. bankruptcy 1 discusses the medical indicators and symptoms of muscle disorder and is designed to let the reader to formulate a differential prognosis at the foundation of the patient's background and actual examination.

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Example text

Normally, muscle fascicles consist of a checkerboard pattern of the two fiber types. With type grouping, this Muscle Disease 34 type II muscle fiber /' type I muscle fiber B . deinnerva tion C . reinnervat ion new collateral sprout I. __ "Q,: large cluster of { type I fibers (type grouping) Figure 2-7. (________ angular fiber Deinnervation and reinnervation. Laboratory Aids for Diagnosing Neuromuscular Disease 3S Figure 2-8. Type grouping (NADH-TR reaction). Muscle fascicles normally contain type I and II fibers in a mosaic pattern.

Note the increasing amplitude of the muscle action potentials at high frequency stimulation (20/sec). the routine EMG study. Thus, unless the electromyographer is informed that the Eaton-Lambert syndrome is a diagnostic consideration, the characteristic electrical findings may be missed. Muscle biopsy Microscopic examination of muscle tissue is not helpful in diagnosing the myasthenic syndrome. Biopsies of such patients may reveal type II fiber atrophy which is probably secondary to the functional block of neuromuscular transmission and disuse.

1 Diagrammatic representation of the pathophysiology of the Eaton-Lambert syndrome. No muscle fiber contraction No MAP ! J. e. 1>0 (') e. :t. , 0 Muscle Disease 50 BOTULISM Ingestion of or exposure to significant amounts of the exotoxin of Clostridium botulinum produces a characteristic symptom complex called botulism. While there are six immunologic types of Clostridium botulinum, botulism in man usually results from the toxins produced by types A, Band E. Type A and B toxin are found in inadequately processed meats, fruits, and vegetables.

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Diagnosis and Management of Muscle Disease by Albert P. Galdi M.D. (auth.)

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