Download e-book for iPad: Deciphering Growth by J.-C. Carel, Paul A. Kelly

By J.-C. Carel, Paul A. Kelly

ISBN-10: 3540261923

ISBN-13: 9783540261926

In mammals, the foremost components concerned with the legislation of physique development are recognized: insulin-like development elements (IGF) are key regulators of somatic development. progress hormone (GH), secreted by way of the pituitary gland, without delay regulates circulating degrees of IGF-I, that's the most important coordinator of spatio-temporal development of the organism. In people, development is much more complicated, related to a few particular features no longer present in different species. those comprise quick intrauterine development, deceleration simply after start, a mid-childhood progress spurt, a moment deceleration prior to puberty, a teen progress spurt, and eventually complete statural progress, that's obvious a little later. The mixed wisdom in regards to the endocrine and paracrine elements of progress have resulted in the advent of remedy regimens, preferable in GH-deficient kids. even if, dimension depends upon the mix of a few genetic elements, and there stay numerous points of this advanced technique nonetheless poorly understood.

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Example text

Our own group have looked at common variations in IRS1 and PPARγ as both have been associated with risk of insulin resistance in adult populations. However, we were unable to confirm any association with size at birth (Mason et al. 2000). Common variation of the ACE gene is related to hypertension and cardiovascular disease risk in adults, and association was observed with size at birth in the ALSPAC cohort (unpublished observations). The mechanism underlying such association is unclear, but ACE is known to regulate metabolism and could influence placental function.

1). The mandrill is the most dimorphic of the primates, with adult males frequently weighing up to three times more than adult females. Among the great apes, the adult male gorilla has a body weight 240% of the counterpart female, the male orangutan weight is 210% of the counterpart female, and the male chimpanzee weight averages 130% of the counterpart female. Although differences in Sexual Dimorphism in the Growth of Homo Sapiens 21 Fig. 1. Ratio of male:female body weight in three different groups of primates, demonstrating that marked sexual dimorphism is largely restricted to Old World monkeys and apes.

Furthermore, the loss of access to tree-climbing might have selected for larger body size as a defense against predators. Among the apes, size dimorphism appears to correlate with social structure and, interestingly, inversely with testicular volume (Short 1994; Fig. 2; Table 1). It has been inferred that among apes,- where a dominant male controls reproductive access to a harem primarily on the basis of his larger size - testicular volume and, by implication, spermatogenic capacity become less important variables.

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Deciphering Growth by J.-C. Carel, Paul A. Kelly


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