By M. Sokovi´c a, J. Mikuła b, L.A. Dobrza´nski b,∗, J. Kopaˇc a, L. Koseˇc c, P. Panjan d, J. Madejski b, A. Piech b
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2005). LIN-12/Notch activation leads to microRNA-mediated down-regulation of Vav in C. elegans. Science, 310, 1330–1333. Zamore, P. , Sharp, P. A. and Bartel, D. P. (2000). RNAi: double-stranded RNA directs the ATP-dependent cleavage of mRNA at 21 to 23 nucleotide intervals. Cell, 101, 25–33. 21 2 Non-coding RNAs – development of man-made vector-based intronic microRNAs (miRNAs) Shao-Yao Ying*, Joseph D. Miller and Shi-Lung Lin Introduction The central dogma of molecular biology is that genomic DNA is transcribed into messenger RNA (mRNA) which is translated into proteins.
J. (2005). The temporal patterning microRNA let-7 regulates several transcription factors at the larval to adult transition in C. elegans. Developmental Cell, 8, 321–330. Hamilton, A. J. and Baulcombe, D. C. (1999). A species of small antisense RNA in posttranscriptional gene silencing in plants. Science, 286, 950–952. , Yeom, K. H. et al. (2004). The Drosha-DGCR8 complex in primary microRNA processing. Genes & Development, 18, 3016–3027. , Johnston, R. , Jr. and Chang, S. (2002). Left-right asymmetry in the nervous system: the Caenorhabditis elegans model.
This book, which focuses on the concepts of microRNA biology, key implications in various forms of diseases, and applications in diagnostic and drug development, consists of thirty-eight chapters, grouped into six sections. Most of the chapters are written by the original discoverers or their associated scientists from academia, biotech and pharma, exclusively from the microRNomics field. Although several reviews have been published covering these tiny molecules, there is no single volume currently available in the marketplace.
Cutting properties of the Al2O3 + SiC(w) based tool ceramic reinforced by M. Sokovi´c a, J. Mikuła b, L.A. Dobrza´nski b,∗, J. Kopaˇc a, L. Koseˇc c, P. Panjan d, J. Madejski b, A. Piech b
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