Download PDF by Kathleen M. Kantak, Joseph G. Wettstein: Cognitive Enhancement

By Kathleen M. Kantak, Joseph G. Wettstein

ISBN-10: 3319165216

ISBN-13: 9783319165219

ISBN-10: 3319165224

ISBN-13: 9783319165226

This publication highlights the behavioral and neurobiological matters appropriate for drug improvement, studies proof for an cutting edge strategy for drug discovery and provides views on a number of unique themes starting from healing drug use in young ones, rising applied sciences and non-pharmacological techniques to cognitive enhancement.

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2001; Passetti et al. 2000). There is also evidence from studies in animal models as well as humans that suggests a role for noradrenergic modulation of attention, with the locus coeruleus (LC) supplying the sole source of norepinephrine (NE) to the cortex, and NE depletion producing deficits in the performance of animals on a variety of attention tasks (Arnsten 1993; Berridge and Waterhouse 2003; Brozoski et al. 1979; Carli et al. 1983; Gamo et al. 2010). Conversely, stimulating the postsynaptic α2A NE receptors in the PFC, either through administration of NE or the selective α2A receptor agonist, guanfacine, increases neuronal PFC firing, and improves attention (Arnsten and Contant 1992; O’Neill et al.

2013; Young et al. 2009a). ” At its core, the RDoC is designed to be translational. Its framework uses a matrix design which groups a functional dimension of behavior based on genes, molecules, cells, circuits, physiology, behavior, and self-reports into “Constructs” and then into higher-level “Domains” that represent system functioning. “Cognitive Systems” is one of five defined Domains in the RDoC matrix and includes the constructs of attention, perception, declarative memory, language, cognitive control, and working memory.

Recognition Memory . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Emotional Memory . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Translatable Biomarkers . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 Electroencephalography . . . . . . . . . . . . . . . . . . . . .

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Cognitive Enhancement by Kathleen M. Kantak, Joseph G. Wettstein


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