By S.R. Pandi-Perumal
Covers medical and pharmacological remedies for varied sleep problems, comparable to insomnia, sleep apnea, narcolepsy, stressed legs syndrome, and periodic limb circulate syndrome. This quantity addresses using sleep drugs in childrens, youth, and within the aged, and likewise bargains an summary of hypnotic medications.
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Extra info for Clinical pharmacology of sleep
2. Schema of the neuronal circuitry that is currently believed to be involved in the pontine regulation of rapid eye movement (REM) sleep progressively disinhibits pontine cholinergic neurons preceding and during REM sleep progressively disinhibits pontine cholinergic neutones of the laterodorsal and pedunclopontine tegmental nuclei (LDT/PPT) via withdrawal of serotonin (5-HT)-mediated and noradrenaline-mediated inhibitory inputs. g. cortical desynchronization end motor atonia, respectively). g.
Serotonin Support for serotonin having a prominent role in the neurochemical basis of upper airway patency is provided by excitation of brainstem dilator motor neurons by local administration of serotonin [23–26], and conversely by reduction of brainstem motor neuron activity by local administration of serotonin antagonists [25, 27, 28]. Identiﬁed serotonergic brainstem motor neurons increase activity linearly with respiratory motor challenges , and nucleus raphe pallidus serotonin-containing motor neurons that innervate brainstem motor neurons implicated in upper airway dilator muscle activity become less active in non-rapid eye movement (NREM) sleep and virtually absent in REM sleep [30–32].
R. Grunstein Psychotropic anti-obesity drugs That particular psychotropic drugs such as the SSRI antidepressants ﬂuoxetine (see also above), sertraline and ﬂuvoxamine may be useful as weight-loss agents was initially suggested by the unexpected observation of weight loss in trials of these agents in patients treated for neuropsychiatric conditions . Subsequently, randomized controlled trials were speciﬁcally designed to assess their efﬁcacy as weight-loss agents in obese patients without neuropsychiatric co-morbidities.
Clinical pharmacology of sleep by S.R. Pandi-Perumal
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