By Amélie Garénaux; et al
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Additional info for Better understanding the Campylobacter conundrum
Survival in water is a particular capacity of campylobacters, which has been widely investigated. The evidence for viable but non-culturable (VNC) forms is highly debatable and may just reflect normal bacterial death-associated changes but there is increasing evidence that biofilm formation  is important and even that intracellular survival in aqueous protozoa  can enhance survivability of campylobacters. 6. Risks to Human Health Campylobacteriosis is a major cause of human enteritis worldwide.
Pylori, CsrA has a broad role in regulating its physiology in response to environmental stimuli . C. jejuni possesses a homologue of CsrA, which could be a key regulator in starvation to mediate the reorientation of the metabolism and to cope with other regulators (Fur and HspR) as it was shown in H. pylori. Conclusion Campylobacter jejuni is considered as a fragile and sensitive bacterium. This discords with the ability of C. jejuni to survive to unfavourable environments such as water and also in the food chain.
Figure 1. Mechanism of lipid peroxidation. From Environment to the Host: 49 Membranes are sensitive to oxidation by both reactive oxygen/nitrogen species. Ozone can react with polyunsaturated fatty acids to form cyclic peroxides, H2O2 and aldehydes . Studies on model and mitochondrial membranes have shown that oxidative attack of phospholipids led to changes in the phospholipids organisation, and to perturbation of the lipid bilayer, possibly leading to membrane breakdown . Effects on DNA Through the Fenton reaction and the production of hydroxyl radicals, H2O2 and O2- are responsible for DNA alteration.
Better understanding the Campylobacter conundrum by Amélie Garénaux; et al
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