By Sonya Vengrova
During the last a long time, nice advances were made in realizing the mobile DNA fix pathways. while, a wealth of descriptive wisdom of human illnesses has been amassed. Now, the fundamental study of the mechanisms of DNA fix is merging with scientific examine, putting the motion of the DNA fix pathways within the context of the entire organism. Such integrative strategy allows realizing of the disorder mechanisms and is valuable in bettering diagnostics and prevention, in addition to designing greater treatments. This publication highlights the relevant function of DNA fix in human overall healthiness and health. The reports provided right here, include exact descriptions of DNA fix pathways, in addition to research of a giant physique of facts addressing hyperlinks among DNA harm fix and human health and wellbeing. they are going to be of curiosity to a wide viewers, from molecular biologists engaged on DNA fix in any version process, to scientific researchers.
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Extra resources for Advances in DNA Repair
The identified cross-linked proteins include those participating in transcriptional regulation, translation, RNA processing, DNA damage response, DNA repair, cell cycle, homeostasis, cell signaling, and cell architecture. These proteomic approaches may have potential applications in the analysis of DNA-damage interactomes . 3. Formation of DPCs DPCs are produced by various chemical and physical agents or during DNA transactions. Here we summarize the formation of DPCs by selected agents including aldehydes, bifunctional alkylating agents, and ionizing radiation.
1111/j. x. A. Arabidopsis Homo‐ logue of Human Transcription Factor IIH/nucleotide Excision Repair Factor p44 Can Function in Transcription and DNA Repair and Interacts with AtXPD. The Plant journal 2006; 46(3) 512–521. x. , Carbonera D. Genotoxic Stress and DNA Repair in Plants: Emerging Functions and Tools for Improving Crop Pro‐ ductivity. Plant Cell Reports. 2011; 30(3) 287-295. 1007/s00299-010-0975-9. , Tuteja R. Molecular mechanisms of DNA damage and repair: progress in plants. Critical reviews in biochemistry and molecular biology 2001; 36 337–397.
Why we should stop inferring simple correlations between antioxidants and plant stress resistance: Towards the antioxidomic era. OMICS 2012; 16(4) 160-167. 0099. , Mittler R. Reactive oxygen species homeostasis and signaling during drought and salinity stresses. Plant, Cell and Environment 2010; 33 453-467. x. , Ariza, R. R. Mutation Research/Reviews in Mutation Research 2009; 681 169-179. E. DNA repair mechanisms in plants: crucial sensors and effectors for the maintenance of genome integrity.
Advances in DNA Repair by Sonya Vengrova